The Senior Dogs Project ..........."Looking Out for Older Dogs" ........... "Blessed is the person who has earned the love of an old dog." - Sydney Jeanne Seward Site Map

Cases in Which Rimadyl Is Suspected or Confirmed as Having Caused Adverse Reactions but Not Death

1998 and Earlier

The following reports are examples of the conditions under which side effects from Rimadyl occurred and the nature of the side effects. Please note that side effects occur in almost every breed and at almost any age (although incidence in older dogs is greater); adverse reactions occur anywhere from after the first dose to months later.

To report an ADE to Pfizer, call: 1-800-366-5288. ADE's should also always be reported to the FDA at: 1-888-332-8387 (or 1-888-FDA-VETS).

Case #50:
Mastiff Experiences "Stumbling"; Recovers after Rimadyl Is Withdrawn
Breed: Mastiff (female, "Harlot")
Age: 6 years
Reason for Rimadyl rx: arthritis due to ACL injury/repair
Dog's weight and dosage taken: 163 lbs 100mg BID
When reaction occurred following initial dose: within 10 days
Symptoms: inappetance, lethargy, stumbling, incontinence
Date of episode: November - December 1998
Did vet seem informed & inform you about side effects? Yes, but stumbling was not one mentioned by Pfizer on package insert
Current condition: recovered
Owner's Remarks: "The above symptoms were easily explained away by me except for the stumbling. I was concerned that the stumbling was not associated with her ACL injury/repair and I could not find an explanation for it. I became aware of the Senior Dogs website from a letter in the AKC Gazette and saw the number of dogs experiencing stumbling/staggering .I immediately took Harlot off Rimadyl. Within 14 days her stumbling stopped, her appetite increased, and she was sleeping less."
druids@erinet.com

Case #49:
Mastiff Loses Senses, Becomes Aggressive after Three Weeks on Rimadyl
Breed: English Mastiff (female, "Gator")
Age: 6 years
Reason for Rimadyl rx: hip dysplasia, arthritis
Dog's weight and dosage taken: 165 lbs./100 mgs. 2X day, 1st week; 1x day, 2nd week; alternate days, 3rd week
When reaction occurred following initial dose: 3 weeks
Symptoms: Loss of sight, smell, hearing; aggressiveness toward owner; extremely high liver enzymes
Date of episode: December 1998
Vet informed about side effects: not specified
Current condition: Rimadyl withdrawn, liver enzymes almost normal after two weeks
Owner's Remarks: "By the third week, she demonstrated aggressive behavior towards me. She seemed to have lost most of her senses -- sight, smell, hearing. I took her to the vet who took a blood sample and found an alarming increase of her liver stats. We immediately took her off the Rimadyl. After about two weeks her stats were almost back to normal. We are now considering two other drugs to help her hip displasia/arthritis."
cori@pe.net

Case #48:
Seizures a Delayed Reaction to Rimadyl?
Breed: Yellow Lab mix (female, "Emma")
Age: 8 years
Reason for Rimadyl rx: hip dysplasia
Dog's weight and dosage taken: 66lbs. - 75 mg twice daily
When reaction occurred following initial dose: 4 1/2 weeks after withdrawal of drug
Symptoms: vestibular signs -- seizure-like episodes
Date of episode: April 18 -22, 1998
Did vet seem informed & inform you about side effects? Nothing was ever mentioned about any side effects
Owner's Remarks: "Four-and-a-half weeks after withdrawing Rimadyl, my 8-year-old Yellow Lab, Emma, had her first seizure. She was lying on her side as a palsy-like tremor of her head began. It lasted one or two minutes. The next day, while she was standing, her eyes grew vacant and her head began to move back and forth as though she were watching a tennis match. These episodes continued for five days. She has been seizure-free for the past nine months, and I am hopeful that she is fully recovered. However, since 'vestibular signs' are noted as a possible side effect of Rimadyl, I am suspicious of the drug as a contributing factor. I do know of the growing numbers of dogs who have taken Rimadyl and suffered seizures . . . which is why I am writing about Emma's experience."
Janet Pfister, Long Beach, CA

Case #47:
Liver Function Test Reveals Problems after One Year on Rimadyl
Breed: Norwegian Elkhound (Spayed Female, Silver Bay's Star Gazer aka "Emma")
Age: 14 years
Reason for Rimadyl rx: arthritic stiffness in hips and rear legs
When reaction occurred following initial dose: marked improvement in mobility within days, no adverse symptoms; problem was noted after six months of daily 75m dosage followed by another 6 months of daily 37m dosage
Symptoms: Vet advised a liver function test after one year on drug, without really explaining why. Initial blood work revealed seriously high liver enzyme levels. Two additional tests pointed to Cushings Disease.
Date of episode: 11/98
Vet informed about side effects: Our initial conversations about Rimadyl's possible side effects indicated that my vet believed that it was quite safe, with side effects noted in only a small number of Retreivers.
Dog's current condition: Fortunately, she is doing very well.
Owner's Remarks: "We stopped giving Emma Rimadyl immediately after getting the results of the liver function tests. My vet wanted to medicate her for the Cushings, but after consulting with several other veterinarians and doing some research of my own on Rimadyl, I asked him to wait for a month, then retest her liver function. After a month with no drugs or medications of any kind in her system, the results of this second test told us what we needed to know. Liver enzyme levels are normalizing and she continues to be visually asymptomatic of Cushings. Her liver enzyme levels continue to be monitored on a regular basis. I have recently read the package insert that the drug company includes with Rimadyl. The verbal info that my vet imparted upon the initial prescription was pretty much a nutshell version of that info. Warnings in the insert focus on the original small number of Retreivers who had negative reactions and doesn't touch on the more recent antecdotal information. If I had read that when the drug was originally prescribed, I would have gone ahead and given it to my dog. I think it's time the FDA made this company update those inserts to be more reflective of the realities of Rimadyl. Had my vet and I been more informed, I think we would certainly have done more frequent monitoring of her liver function and very possible that we would have used alternative methods of dealing with Emma's stiffness (which, by the way, has not returned). As a caring professional, my vet will absolutely be discussing the possible side effects of this drug in a more complete way in his practice, and I am very grateful to those people whose sharing of their experiences has helped me to help my beloved friend.
12/21/98
NTANTIQUES@aol.com

Case #46:
Immediate Reaction of Bloody Stool
Breed: Chocolate Labrador (male, "Augie")
Age: 12 years
Reason for Rimadyl rx: arthritis
When reaction occurred following initial dose: immediate, after one tablet; same reaction after dose reduced to one-half tablet
Symptoms: bloody stool
Date of episode: June 1998
Vet informed about side effects: vet prescribed Glycoflex and Rimadyl; inquired whether dog had ever reacted negatively to aspirin
Current condition: recovered
Owner's Remarks: "The vet examined him and prescribed Glycoflex and Rimadyl. Before presribing the Rimadyl, the vet did ask me if my dog was able to use aspirin without incident. I gave him one Rimadyl tablet and almost immediately he was having bloody bowel movements. I immediately stopped the medication and called the vet who told me to wait two days and try again, this time with half a tablet. Two days later I got essentially the same response."
mshapiro@blackrock.com
12/22/98:
This is an abbreviated report; complete report available upon request to: rimreport@srdogs.com

Case #44:
Breed:Springer Spaniel/Austrailan Shepherd mix (female "Brittany")
Age: 14 1/2 years
Reason for Rimadyl rx: slight stiffness in rear legs
When reaction occurred following initial dose: 2 weeks
Symptoms: inappetance, refusal to drink, vomiting, staggering, dizziness
Date of episode: October 26 - November 10, 1998
Vet informed about side effects: No side effects were
mentioned, did say that it wouldn't cause stomach upset.
Current condition: Rimadyl withdrawn; vet will do blood tests in a few days (November 24, 1998)
Owner's Remarks: "Brittany has had a relatively illness- free life, and for her to appear so near death in such a short time was agonizing for our family. I am hopeful that we have stopped the Rimadyl in time to not have done permanent damage. The first symptom started the day I reduced the dosage to 1/2 tablet a day instead of twice a day; she seemed to stagger and lose her balance, but seemed to recover for a few days. The following week she was staggering daily and not eating at all. We took her into the vet on Friday (November 20) and he x-rayed her neck and diagnosed her with degenerative spine disease. He put her on Prednisolone and said we may see improvement by Monday. I did question if her condition could be caused by a drug interaction. (She was already on Phenylpropanolamine for incontinence). By Monday she was not any better at all. Last night I just happened on this website and this article about Rimadyl and couldn't believe what I was reading. It matches her symptoms exactly. I hope we caught it in time."
YHTCT4@aol.com

Case #43:
Breed: Miniature Schnauzer (male)
Age: 3 years
Reason for Rimadyl rx: limp of unknown cause
When reaction occurred following initial dose: 5 weeks
Symptoms: weakness, lethargy, inappetance, refusal to drink
Date of episode: October 30, 1998
Vet informed about side effects: NO; definitely NOT!
Current condition: fighting to survive autoimmune hemolytic anemia
Owner's Remarks: "This drug should be withdrawn as far as I am concerned. Our dog was perfectly healthy until given Rimadyl. He took the drug for only 10 days and within 4 weeks went from a healthy, active dog to barely alive. He is currently on 40 mg of predisone a day to fight the anemia. This disease struck without warning and with no apparent cause -- except for the Rimadyl -- which never helped his limp anyhow. I would never ever have given him this drug, if I had been advised of the potentially deadly effects."

7/12/00 -- Update on Case #43: "It is now almost two years since our beloved mini Schnauzer almost died. He is now five years old. Since his last crisis in May 1999, he has remained in remission from the auto-immune hemolytic anemia that we believe was a result of his taking Rimayl. We periodically have blood work done to evaluate his condition and continue to treat him normally. However, we cannot give him any vaccinations, and, therefore, he will soon lose his immunity to normal canine diseases such as parvo He cannot be kenneled because of this. It makes me so upset and angry to know that many vets are still administering this drug indiscriminately and with no warnings and to very young and healthy dogs with minor injuries or post surgically as was given to our dog. To date, Pfizer has promised us many times to pay for tests and treatment related to the Rimadyl. However, despite the fact that they have all our records, we have had no contact within the past year and never received any reimbursement. Why is the FDA allowing this drug to be marketed and sold with all the mounting evidence against it?"
Rbbears4@aol.com

Case #42:
Breed: Australian Shepherd (female, "Libby")
Age: 13.5 years
Reason for Rimadyl rx: arthritis of spine
When reaction occurred following initial dose: 9 months; more severe reaction after 3 weeks when dosage was doubled
Symptoms: continuous heavy panting and sensitive stomach; then stumbling, shaking head, vomiting, dizziness, and panting when dosage was doubled
Date of episode: Spring - Fall 1998
Vet informed about side effects: Vet did not warn of side effects; advised doubling dosage when dog began excessive panting (150 mg/day for 40-pound dog)
Current condition: Dog continues to be dizzy, stumbling
Owner's Remarks: "The vet insists the dog's condition is due to an inner ear disorder."

Case #41:
Breed: German Shepherd (male, "Baron")
Age: 4 years
Reason for Rimadyl rx: arthritis
When reaction occurred following initial dose: within 72 hours
Symptoms: stumbling, falling, loss of use of back legs
Date of episode: Rimadyl started 10/31/98; reaction 11/2/98
Vet informed about side effects: Vet did not warn of side effects; indicated medication would improve dog's condition
Current condition: Tail moves in a circular motion, dog falls, drags back feet, sits on knuckles, walks on knuckles, has no sense of balance at all
Owner's Remarks: "Baron had elbow dysplasia when he was 6 months old. We had elbow surgery performed on him and knew that he'd always be arthritic. The last week of October 1998, he became arthritic and stiff. We'd heard about the wonder drug for dogs - Rimadyl - and we took him to the vet right away to have him put on it. The vet confirmed that he should be placed on Rimadyl, and he prescribed 75 mg twice a day. We gave him his first pill on the 31st of October. By the 2nd of November he could not walk straight, his tail wagged in a circular motion and he was having extreme difficulty pulling himself up to walk. It's as though he's numb in his hindquarters. Baron visited the vet on 11/5/98 and was taken off the Rimadyl and prescribed cortisone, dosage to begin 11/7/98. The veterinarian now says that Baron has a degenerative spine disease and gives him 2-3 months to live. This happened overnight. I strongly suspect Rimadyl is responsible. My vet has told me that this type of symptom is not indicative of a reaction to Rimadyl. I find it strange that it happened within 72 hours of my dog taking the drug."
MarleneT@aol.com

Case #40:
Breed: Black Lab (male, "Duke")
Age: 7 years
Reason for Rimadyl rx: minor arthritis
When reaction occurred following initial dose: 2 weeks
Symptoms: inappetance; vomiting; liver toxicity
Date of episode: August - September 1998
Vet informed about side effects: Vet did not warn of side effects
Current condition: Improved after owner designed nutrition plan to counteract serious appetite depression (click on Complete Report below for details)
Owner's Remarks: "Duke had to be hospitalized and was placed on intravenous fluids. I came home distraught and unsure whether he would return home again.  I got on the Internet and was amazed to find so many personal accounts of the same experiences of so many unsuspecting pet owners before me.  Why was I not informed of the possibility of side effects?  Or symptoms of adverse reactions to watch for? We should not have to do our own research when we pay professionals to be educated and to share their education with us."
hillnjen@rochester.rr.com
This is an abbreviated report; complete report available upon request to: rimreport@srdogs.com

A follow-up report to Case #40:
"Nothing Has Changed: Tonight I took my two Labrador Retrievers to a new vet for the first time since my eight-year- old male recovered from life-threatening liver toxicity as a result of 2 1/2 weeks on Rimadyl. As I have lost faith in the vet who prescribed Rimadyl without informing us of the possible side effects or symptoms that would warn of trouble, I need to find a new vet.  While I was in the waiting room, a pet owner was given a bottle of Rimadyl for her 18- year-old Golden Retriever.  I wanted so much to follow her into the parking lot to ask whether she had been informed of the potential side effects of the drug. I met with the vet and discussed with him Duke's arthritic knee, which is a result of a previous injury from years ago.  I advised him that Duke had been taking Glycoflex for a couple of months, but did not tell him of our Rimadyl experience.  I wanted to see whether he suggested it as an option. To my amazement, he did.  He did not offer any information regarding side effects or adverse results from Rimadyl use. When will anything be done to require that vets at the very least provide the necessary information to pet owners so that WE can make the decisions we know to be best for our beloved companions who trust us completely with their lives and well-being? Is there some profit incentive being offered by Pfizer to promote this drug's use?  I am having a very hard time comprehending why vets are persisting in the widespread use of this drug with such clear-cut evidence for serious concern. Especially with Labrador Retrievers."
hillnjen@rochester.rr.com

Case #39:
Breed: Black Lab/Shepherd Mix (male, "Holden")
Age: 1 year
Reason for Rimadyl rx: shoulder joint pain
When reaction occurred following initial dose: one day
Symptoms: restlessness, whining, anxiety, hyperactivity followed by periods of lethargy and aggressiveness
Date of episode: October 25, 1998
Vet informed about side effects: Vet said absolutely nothing about any side effects. "I was led to believe that it was a safe medicine that was routinely prescribed."
Current condition: Holden seems to be doing okay. He is lying beside me chewing his squeeky strawberry toy right now.
Owner's Remarks: "Holden was struck by a truck in our parking lot. We took him immediately to his vet. She ran a series of x-rays and said that his shoulder joint had popped out of its socket but, because of his youth, it had gone right back. She released him the same day after prescribing Rimadyl to help him with the pain. That night we began to notice a difference in Holdy's behavior, but we chalked it up to his having a REALLY bad day. The next morning and the following evening, Holden began exhibiting extreme anxiety and became excessively vocal (he has always been a non-whiner). I guess it was instinct that led me to suspect something was wrong. I researched Rimadyl on the net and stopped giving him his medication that night. Only three days have passed, but Holden has returned to his normal self. I spoke with another vet, and she told me that I should continue to watch him, but testing isn't really needed due to the short duration that he was medicated. If something should come up, however -- any change in urination or drinking habits -- we will take him in for a complete blood workup."
Buffydavis@aol.com

Case #38:
Breed: Cocker Spaniel (female)
Age: 2 years
Reason for Rimadyl rx: arthritis
When reaction occurred following initial dose: after first pill
Symptoms: flatulence; sluggishness; inappetance; repetitive violent vomiting
Date of episode: Fall 1998
Vet informed about side effects: assured owner the drug was very safe
Current condition: recovered
Owner's Remarks: "I got scared because she became so violently ill. I called the vet and was again told that they give this drug to hundreds of dogs, and she had never heard of such a severe reaction... I am back to the holistic world. My dog is having acupuncture treatments and is taking herbs. I've also been giving her glucosamine and she's fine! She's out of pain and plays like the puppy she is..."
Joan

Case #37:
Breed: Yellow Lab (male)
Age: 8 months at time of Rimadyl administration
Reason for Rimadyl rx: hip dysplasia/limping
When reaction occurred following initial dose: 4 days
Symptoms: sort-of seizure -- face contorting, lips pulled back as is snarling; diarrhea
Date of episode: September 1997
Vet informed about side effects: No
Current condition: fine; no lasting after-effects
Owner's Remarks: "He was on the pills 4 days, and when I went to let him outside in the morning, he acted very peculiar. I wasn't sure if he was having a sort of a seizure or . . . wanted to bite me. His face was contorting, he was jerking, and his lips were pulled back in a snarl, but there was no sound. I was afraid to touch him. I backed away and went up to call the vet. I know my dog; he is sweet and gentle and wouldn't hurt a flea! When we later went to the orthopedic specialist, I asked her if she had heard of a reaction to Rimadyl such as my dog has had. She said no. One day later, she called me to tell me she had checked and found there was a study being done on similar episodes of a toxic reaction to Rimadyl. Thank God, I took him off the drug as soon as possible! He is not suffering any long-term effects."
Peppi15671@aol.com
This is an abbreviated report; complete report available upon request to: rimreport@srdogs.com

Case #36:
Breed: Chow-Golden Retriever mix (male, "Pookie Bear")
Age: 5 1/2 years
Reason for Rimadyl rx: hip dysplasia/arthritis
When reaction occurred following initial dose: weeks
Symptoms: vomiting and intestinal cramp episodes; resstlessness; pacing; imbalance; inappetance; hair loss; hot spots; personality changes; bleary, glazed eyes; inner ear itching and pain; urination in the house
Date of episode: May to October 1998
Vet informed about side effects: No
Current condition: much improved
Owner's Remarks: "We adopted Pookie Bear a year ago and while his appearancehad been neglected, he was in good general health. The owners also gave us a printout of his previous vet records, which showed an uneventful history. A trip to our vet revealed the hip problems and we started Adequan injections immediately, which provided positive results. He settled into his new home well and was healthy & happy. After a few months the vet insisted that we start him on Rimadyl, for 'long-term therapy.' We started giving Pookie Bear the Rimadyl in May 1998. That's when he started falling apart (see Symptoms, above). After a couple of months of these symptoms they tested his thyroid levels and those were low, so we started him on Thyrosyn, which only helped with the hair loss. During this series of illnesses, problems, bags of WD formula dry kibble, and mounting vet bills over the past six months, all we got were vague diagnoses of 'irritable bowel syndrome' and allergies. (Note: We don't use harsh chemicals in the house or in the yard.) The vet did no preliminary blood work before prescribing the Rimadyl and did not describe potential side effects; when I asked about it, she said they were 'nothing to worry about.' Pookie weighs 60 pounds and the Rx was for 75 mg twice a day. Even Pfizer directs dosage as 1 mg per pound of body weight. Thank goodness we were only giving him one pill at night. I found this website 10-23-98 and that night the Rimadyl went in the trash. We started homeopathic treatments and raw diet (see recommended Reference Books on the website). He has shown steady improvement. The hair shaved to treat the hot spots started growing faster immediately after taking him off the Rimadyl. His gait is steady, eyes are clear, and he rests quietly at night. He has run of the house, and there has been no soiling. A conference with the regular vet and subsequent blood test for potential liver/kidney damage are pending, not to mention what may have happened to his thyroid. I called Pfizer to report an ADE and the vet there said that we did the right thing -- 'you were your own best vet' -- by taking Pookie off Rimadyl, that it was obvious it didn't agree with him. I look at this like voting -- you can't change the status quo by yourself, but your vote, along with others who vote the same way, creates a voice. So here's one more ADE about Rimadyl, and one more dog's owners speaking to a vet about it. Oh, and to every other dog owner they know..."
Update November 23, 1998: "We took Pookie Bear to a different vet last week for a checkup and complete blood workup. He had no thyrosin for 24 hours before the checkup. He has been off Rimadyl and on a natural diet for one month. He looks good, is holding steady at 62 pounds, and the blood work came back NORMAL --including his thyroid levels. We don't have to continue the thyrosin, and he has no liver or kidney problems! We continue to notice the positive changes in him -- mellowing out and wanting to be close, as well as his overall energy level and appearance. We have our dog back. Maybe his liver and kidneys weren't affected, but what about his thyroid? Seems like it to me."
hhasting@ix.netcom.com

Case #35:
Rimadyl Suspected of Causing Blindness and Deafness (Stroke?)
Breed: Poodle (male)
Age: 13 years
Reason for Rimadyl rx: arthritis
Symptoms: massive amount of blood in urine
When reaction occurred following initial dose: 2 days
Date of episode: September 1998
Vet informed about side effects: did not do pre-test or inform owner
Current condition: Rimadyl withdrawn, dog recovering
Owner's Remarks: "We were in the mountains and it was cold and damp, so I gave my dog a dose of Rimadyl several days in a row rather than his regular intermittent schedule. He went blind and deaf and was in a daze; in fact, I felt he was close to death. I took him off Rimaldyl and took him to a vet who gave him tests and antibiotics but never said that it could be Rimadyl. . . . I have later heard from my new vet that she would have not prescribed Rimaldyl without first doing some kind of tests."
LMcKee1065@aol.com

Case #34:
Rimadyl Suspected of Causing Seizures
Breed: Bullmastiff (female)
Age: 9 years
Reason for Rimadyl rx: stiff joints
When reaction occurred following initial dose: not specified
Symptoms: seizures
Date of episode: September 1998
Vet informed about side effects: not clear
Current condition: not specified
Safes@net1.net

Case #33:
Rimadyl Suspected of Causing Blood in Urine
Breed: Golden Retriever (female, "Samantha")
Age: 6 years
Reason for Rimadyl rx: limping
Symptoms: massive amount of blood in urine
When reaction occurred following initial dose: 2 days
Date of episode: September 1998
Vet informed about side effects: did not inform owner
Current condition: Rimadyl withdrawn, dog recovering
Owner's Remarks: "The vet obtained a urine sample . . . and said 'Oh, my God!' There was so much blod, she didn't know if she could do a urinalysis. She told my husband to discontinue the Rimadyl and gave Samantha two shots to 'neutralize' the effects of the Rimadyl. Sam seems to be fine, now, thank Goodness! But, when I think of how fast the negative side effects started, I am very alarmed! The vet never warned us of any potential side effects, and we didn't get a copy of any product insert. I strongly recommend that if anyone's vet recommends Rimadyl, they ask about the side effects -- no matter how rare they are supposed to be. Get a copy of the product insert that should come with any medication. I know this drug helps some dogs; a friend of mine has a Collie-Shepherd mix for whom it is working great. But, it doesn't work for all dogs. Be sure you learn about the side effects before you put your best friend on it."
ENGLISH.CM@prodigy.net
This is an abbreviated report; complete report available upon request to: rimreport@srdogs.com

Case #32:
Rimadyl Probably Inhibits Bone Healing
Breed: German Shepherd/Collie Mix (female, "Georgina")
Age: senior
Reason for Rimadyl rx: osteoarthritis
Symptoms: leg fracture did not heal properly over a period of months
Date of episode: April - July 1998
Current condition: healing occurred after Rimadyl was withdrawn
Owner's Comments: " My doctor ... said that at the hospital he's with, patients with bone fractures and bone surgeries are never given ibuprofen-family drugs because they feel it inhibits bone healing and it lessens the pain and consequently the patient uses the injured area too soon. Four weeks after stopping the Rimadyl and switching her food, Georgina's x-ray showed that the fractured area, which had been about ten percent healed, was suddenly better than NINETY PERCENT healed. Our veterinarians both at home and at University of Illinois took notice of this and seemed dismayed that this bone-healing side effect was not included in any of the drug's literature."
dogacres@chicagonet.net
This is an abbreviated report; complete report available upon request to: rimreport@srdogs.com

Case #31:
Breed: Chocolate Labrador Retriever (male, "Bucky")
Age: 5 years
Reason for Rimadyl rx: hip dysplasia and arthritis
When reaction occurred following initial dose: 21 days
Symptoms: loss of appetite; pasty stools; jaundice; weight loss; dark urine
Date of episode: August 1998
Vet informed about side effects: Yes; performed blood test after 10 days; also informed owner of side effects
Current condition: Rimadyl withdrawn, but symptoms persisted for several days; dog now "pretty much back to normal"
Owner's Remarks: " My vet did advise me that there was a possibility of problems, hence the blood test after 10 days. They also did a good job of letting me know what symptoms to watch for, which is how we caught it so quickly. During his recovery, we fed Bucky rice, boiled chicken and cottage cheese, as our vet advised. This got him to start eating again, and within 4-5 days he was pretty much back to normal. Bucky is now doing great -- even seems to be walking better. Probably just has a better outlook now that he's not sick anymore!"
Steve.Adams@inteq.bhi-net.com

Case #30 with Update:
Breed: Labrador Retriever (female, "Go-go")
Age: 10 years
Reason for Rimadyl rx: arthritis in front wrists
When reaction occurred following initial dose: 1 day; 3 weeks
Symptoms:vomiting and lethargy, seemed to drink less than usual
Date of episode: July - August 1998
Vet informed about side effects: not clear
Current condition: Rimadyl withdrawn, vomiting stopped initially, but has now returned
Owner's Remarks: "Go-go had colitis about 3 years ago and has had an 'iffy' stomach ever since. But, she did seem to get used to Rimadyl and had much improved movement of her legs. She began to enjoy going for walks again. Then I observed that Go-go was no longer drinking water the way she used to. After 3 weeks, she vomited during the night. We withdrew Rimadyl and had about a week of no vomiting, but now it has started again. The vet has suggested something to replace both Rimadyl and Glycoflex. I hope I'll have a good outcome to report."
Update 9/12/98: "Go-Go is home after several nights of vomiting for the vet. Her blood work/profile did show some liver damage. Concurrent with all this is the possiblity that she has swallowed something which at this point is partially blocking her small intestine. Waiting to see what comes to pass (so to speak). She is now on Medrol and Metronidazole and SynoviCre (for her joints) and Derm Caps (for her skin) NO MORE RIMADYL
Npbale@aol.com

Case #29 with Update:
Breed: Siberian Husky (male, "Damien")
Age: 9 years
Reason for Rimadyl rx: joint pain
When reaction occurred following initial dose: 1 day
Symptoms: uncontrollable panting; pacing; restlessness
Date of episode: August 29 -31, 1998
Vet informed about side effects: vet never informed owner of any side effects
Current condition: recovering
Owner's Remarks: "Damien's reaction scared me terribly. He and my other dog and three cats are my children. It hurts me when they are sick or inuured, but, when it's my fault for giving them medication that's supposed to help but only makes them worse, it kills me. What makes me really mad is the vet did not tell me about any side effects. When I called her, she said that she did not do a work-up because she only uses Rimadyl sparingly, and she was sure that Damien would be fine because Rimadyl has bad side effects only with Labs."
October 2, 1998 Update: "Damien has been doing great. I don't think that I would have caught his reaction so soon if I had not seen this web page and if I had not been watching him so closely. I have not called Pfizer or the FDA yet with the ADR, because I felt that I should calm down first. I will call them soon. I am going to have my vet do a blood work-up on Damien to make sure that there are no long-term effects."
MClem1229@aol.com

Case #28:
Breed: Dobie Mix (female, "Gidget")
Age:12.5 years
Reason for Rimadyl rx: arthritis in back legs
When reaction occurred following initial dose: 3 - 4 weeks
Symptoms: weight loss, panting, heavy breathing, lethargy
Date of episode: Summer 1998
Vet informed about side effects: NO; did not warn owner
Current condition: liver/kidney failure, congestive heart failure
Owner's Remarks: "I thought Rimadyl was safe. I thought that if it were not safe my vet would have told me! I should have been informed. I can't prove the connection; but I know it is connected simply because of Gidget's previous health and the timing."
JBTRUS@AOL.COM
This is an abbreviated report; complete report available upon request to: rimreport@srdogs.com

Case #27:
Breed: Shih Tzu (male)
Age: senior
Reason for Rimadyl rx: shoulder pain
When reaction occurred following initial dose: no overt reaction; but apparent liver damage
Symptoms: blood work shows liver damage
Date of episode: Summer 1998
Vet informed about side effects: told owner drug had "virtually no side effects and was very safe in older dogs"
Current condition: dog diagnosed with Valley Fever; medicine for cure is metabolized by liver; since Rimadyl caused liver damage, medicine cannot be administered
Owner's Remarks: "The lab reports are back and the news is not good. My Shih Tzu has Valley Fever, an illness mostly found in the Southwestern US. The meds he needs to take for Valley Fever are metabolized by the liver. Rimadyl has caused damage to his liver. If I give him the meds for Valley Fever, he'll probably go into liver failure. If I don't give him meds for Valley Fever, he'll die. Samantha, my Miniature Schnauzer died five weeks ago from the side effects of Rimadyl. Her story below, is Death #1. I cannot stand to watch another dog die the way Samantha did."
NoURAPutz@aol.com
This is an abbreviated report; complete report available upon request to: rimreport@srdogs.com

Case #26:
Breed: German Shepherd (neutered male, "Zeus")
Age: 16 months
Reason for Rimadyl rx: lameness in hind leg
When reaction occurred following initial dose: 5 days
Symptoms: seizure, lethargy
Date of episode: August 12, 1998
Vet informed about side effects: side effects mentioned were vomiting, diarrhea, loss of appetite
Current condition: continues to be on Phenobarbitol as "precaution" for seizure, and off Rimadyl...still awaiting results of blood tests (CBC & SMA 12+)
Owner's Remarks: "We saw improvements in Zeus after the second day of treatment with Rimadyl. He was on 200mg the first 3 days and then 100mg the following days -- until the seizure. The vet will not say the seizure was from Rimadyl, but Zeus is healthy otherwise. It is so sad to hear of the deaths related to Rimadyl. We feel so fortunate our dog did not die!!"
Pppiglet23@aol.com
Case #26 Update: "I have contacted both the FDA and Pfizer who listened empathetically and took pertinent information. I owe Zeus' recovery to finding the srdogs website where the information has helped tremendously!! Still recovering!"

5/24/99: Update to Case #26:
"Unfortunately my news is not good. I am sorry it has taken a while to send this update on Zeus, but it is so hard for us. Zeus passed away on 12/23/99. We don't know what went wrong. First it was the Rimadyl that led to the seizures and then to the phenobarb and then to what the vet thinks was neurological damage. In Zeus' final days he could not walk and his left side was failing. He died in his sleep. He will be missed; he was such a good pal."
Breed: German Shepherd (neutered male, "Zeus")
Age: 16 months
Reason for Rimadyl rx: lameness in hind leg
When reaction occurred following initial dose: 5 days
Symptoms: seizure, lethargy
Date of episode: August 12, 1998
Vet informed about side effects: side effects mentioned were vomiting, diarrhea, loss of appetite
Current condition: continues to be on Phenobarbitol as "precaution" for seizure, and off Rimadyl...still awaiting results of blood tests (CBC & SMA 12+)
Owner's Remarks: "We saw improvements in Zeus after the second day of treatment with Rimadyl. He was on 200mg the first 3 days and then 100mg the following days -- until the seizure. The vet will not say the seizure was from Rimadyl, but Zeus is healthy otherwise. It is so sad to hear of the deaths related to Rimadyl. We feel so fortunate our dog did not die!!"
Pppiglet23@aol.com

Case #25:
Breed: Beagle (female, "Lucky")
Age: 11 years
Reason for Rimadyl rx: vet suggested as "better than Cosequin"
When reaction occurred following initial dose: about 2 months
Symptoms: urinary incontinence
Date of episode: Summer 1997 we took her off of Rimadyl and the bladder infections went away.
Vet informed about side effects: Vet diagnosed bladder infection; however, tests revealed no bacteria, no bladder problems, no kidney problems; vet did not believe the condition was Rimadyl related; said he had not heard about side effects or been informed by Pfizer
Current condition: worse hobbling than when put on Rimadyl; is on special food for "early stage" kidney problems
Owner's Remarks: ". . . I thought that I would alternate Rimadyl and aspirin to keep her from developing a tolerance and to give her stomach a break, but the DAY that I tried the Rimadyl again, she immediately urinated in the house. We stopped Rimadyl again, and the accidents stopped immediately. I tried Rimadyl to improve the condition of my older dog's life, and instead, it has harmed her. Worse, the vets are not aware to watch for problems to develop, or to suggest switching drugs after a week or so, so that these kidney and bladder problems do not develop. I believe that Rimadyl is no different than giving your dog Ibuprofen, and that the same precautions should be observed."
KappyH@ibm.net
This is an abbreviated report; complete report available upon request to: rimreport@srdogs.com

Case #24:
Breed: Akita (male, "Kobe")
Age: 9 years
Reason for Rimadyl rx: limping; diagnosed with a strained muscle
When reaction occurred: 3rd day of use
Symptoms: bloody vomit and diarrhea
Date of episode: 11/97
Vet informed of side effects: yes
Current Condition: poor; never fully recovered
Owner's Comments: "Our dog has 'aged' quickly since the episode and never really recovered his spirit or strength. He was eventually diagnosed with a torn anterior cruciate ligament. Due to his over-all poor health now, the vet is very negative about surgery. He is lame and we will keep him quiet until we feel he has lost all quality of life. He was on Prednisone (10mg e/o day) for allergies at the time. The vet gave him Rimadyl and erythromycin at the same time. If there is a problem with combining these drugs, I hope the vets are informed!"
Dmgobeach@aol.com

Case #23:
Breed: .Miniature Poodle (male, "Brutus")
Age: 14 years
Reason for Rimadyl rx: Arthritis
When reaction occurred following initial dose: very soon after; can't say exactly
Symptoms: excessive thirst, urination, incontinence (copious "accidents" throughout the day and night); staggering, stumbling, toppling
Date of episode: August 1998
Vet informed about side effects: told owners Rimadyl had no side effects
Current condition: except for excessive thirst and incontinence, good; has arthritis and underactive thyroid
Owner's comments: "There have been occasions when we have had so many accidents so close together that the previous day's carpet-cleaning sessions sometimes haven't even thoroughly dried before we were going through the blot-treat-dry-vacuum process all over again. We can't sleep through the night for getting up to put him out constantly--some nights it is every hour or so. Just a couple of days ago I was expressing our frustration and upset over this--the suggestion was made that he may be at the end of his normal life. Brutus has brought us many years of love and joy; we refuse to have our wonderful dog put down just because he's turning into a maintenance hassle. We are very hopeful that discontinuing the Rimadyl will help."
michele@ang.org
This is an abbreviated report; complete report available upon request to: rimreport@srdogs.com

Case #22:
Breed: Small Mix (female, "Gypsy")
Age: 14
Reason for Rimadyl rx: stiffness
When reaction occurred following initial dose: 4 days
Symptoms: confusion; walking in circles; stumbling; rapid eye movement; vomiting; mucoid, bloody stool
Date of episode: July 1998
Vet informed about side effects: prescribed via telephone with no warning to owner of side effects; diagnosed "stroke"
Current condition: recovering
Owner's Remarks: "Since reading that so many others have had similar experiences, I have concluded that Rimadyl probably was responsible for what happened to Gypsy. I plan to continue to keep a close watch on her. I was encouraged to learn that some have recovered and so saddened to hear about the fatalities."
Case #22 Update: "I am very pleased to report the progress that my dog has been making in recovery from her experience with Rimadyl. It took about two weeks for Gypsy to get her appetite back and regain some degree of coordination. She still has some balance and coordination problems that were not there before Rimadyl. The vomiting, diarrhea and rapid eye movement have stopped. However, she is not the same dog as before we gave her Rimadyl. Gypsy had been given only a small amount of the drug and received aggressive treatment immediately at the vet when she experienced her adverse reaction. I have been in touch with the vet at Pfizer, and he has been working with the information from the blood samples that my local vet has been taking from Gypsy. My vet reports that 'her numbers' are good regarding liver function. I understand that this information will be used in Pfizer's data base on the effects of Rimadyl. My local vet has said that he will not prescribe the drug again unless he does a blood work-up first. Thanks to the Senior Dogs Project for posting this problem on the Internet. If I had not read about it, I might have had my dog put to sleep."
susanEinmiami@worldnet.att.net

Case #21:
Breed: Westie (female, "Mandy")
Age: senior
Reason for Rimadyl rx: athritis in left hind knee
When reaction occurred following initial dose: 2 weeks
Symptoms: depression; inappetance; non-stop vomiting; black stools; hemmorhaging
Date of episode: December 1997
Vet informed about side effects: NO
Current condition: recovering; continued monitoring
Owner's Remarks: "She is still not completely herself, but I attribute that to the steroids. She still goes in once a week to have her blood checked. I would feel better if they (Pfizer) had a handout that explains the warning signs for what can be irreversible toxic poisoning."
BIGBLUE44@aol.com

Case #20:
Breed: Labrador (male)
Age: senior
Reason for Rimadyl rx: degenerative athritis
When reaction occurred following initial dose: 13 days
Symptoms: anorexia; liver toxicity
Date of episode: December 1997
Vet informed about side effects: YES
Current condition: recovered
Owner's Remarks: "I believe there many other pets who have experienced problems but , like me, their owners have left it unreported simply because they did not know where or how to report the problem."
sneaker@execpc.com

Case #19:
Breed: Golden Retriever (female, "Haley")
Age: 12.5 years
Reason for Rimadyl rx: arthritis; fused vertebrae
When reaction occurred following initial dose: 13 days
Symptoms: inappetance; vomiting; fever; liver toxicity; tilting-and-bobbing of head (vestibular signs); paralysis; imbalance
Date of episode: January 1998
Vet informed about side effects: NO; initially increased Rimadyl dosage, looked for signs of infection, growths, blockages, but found none
Current condition: recovered
Owner's Remarks: "The vet had no clue what was wrong with her. On Monday morning we called the Pfizer 800 Help line. We spoke with one of the staff vets. He said she had signs of a toxic reaction to Rimadyl, to stop giving it to her immediately and take her to our vet and have her put on I.V. to regain some strength and fluid. He was very helpful and probably saved her life. Our vet said he had heard rumors about problems with Rimadyl but wasn't sure about it."
vale@rof.net

Case #18:
Breed: Springer Mix (male, "Barney")
Age: 13 years
Reason for Rimadyl rx: arthritis
When reaction occurred following initial dose: 25 days
Symptoms: inappetance; vomiting; urinary infection; blood & glucose in urine; sky-high liver enzymes
Date of episode: Summer 1997
Vet informed about side effects: NO; suspected cancer or cirrhosis of liver; recommended euthanasia
Current condition: recovered -- and has, since his Rimadyl episode, celebrated his 14th and 15th birthdays in July 1998 and 1999
Remarks on Dog's Rimadyl Experience: "I asked my vet three times during his illness and slow recovery, if he could be having a reaction to the Rimadyl. Each time she said 'no.' A few days after we brought him home, my vet suggested we begin to consider euthanasia. A couple of months after he recovered and more information had been sent to the vets about Rimadyl, my vet agreed with me. I could have euthanized my dog because he was having an adverse reaction to a drug! Had I listened to my vet, Barney's death would have been attributed to old age, not Rimadyl. My vet suspected cirrhosis or cancer of the liver because of the results of an ultrasound. "
jeanw@itscomp.com
Additional Notes on Case #18:
September 28, 1998: "How many dogs were euthanized needlessly as Barney would have been, had I taken my vet's word as gospel? How many dogs died from Rimadyl with the cause noted on the record as "old age, liver failure," etc.? I don't believe the adverse reactions occur in as small a percentage of dogs as Pfizer claims. Perhaps many dogs have been helped by Rimadyl. If this is truly the case, Rimadyl shouldn't be removed from the market. I believe the veterinarians must inform the pet owner of the possible side effects! Dogs can't speak to us and tell us what is wrong; the owners need to know what to watch out for, so the drug can be stopped immediately. Only the informed owner can make the choice as to whether to start the drug and when to stop so their dog doesn't die needlessly!"
jeanw@itscomp.com
August 2000: Barney went to Rainbow Bridge on August 9, 2000. He died of kidney failure. He lived for three years after his near-fatal reaction to Rimadyl.

Case #17:
Breed: Mixed Breed (female)
Age: 13 years
Reason for Rimadyl rx: lameness
When reaction occurred following initial dose: 2 months
Symptoms: balance problems; internal bleeding; inappetance; incontinence; low platelets
Date of episode: Summer 1997
Vet informed about side effects: NO; owner informed him
Current condition: still recovering
Owner's Remarks: " I reported it to Pfizer. The vet I spoke to at Pfizer was very interested and asked me many questions. He even asked that my vet contact him. My vet was amazed at what I told him I learned. He asked me to print out everything so he could read it. We are still looking into whether Rimadly was to blame or not."     
Bacteria40@juno.com

Case #16:
Breed: Rottweiler (female, "Carly")
Age: 3 years
Reason for Rimadyl rx: preventive medication for mild hip dysplasia
When reaction occurred following initial dose: 3 days
Symptoms: lethargy, inappetance; collapse
Date of episode: May 1998
Vet informed about side effects: NO; insisted symptoms were not related to Rimadyl; Pfizer vet differed and directed Rimadyl be discontinued
Current condition: recovered
Owner's Remarks: "The vet from Pfizer was very upfront with me and called my vet immediately. He has since called me and my vet at least once a week for updates. He said even HE thought the drug was involved. Pfizer has said they will pay for all the diagnostic work. I do want to say that the vet from Pfizer was very helpful and did a good job of following up with both me and the vet. That does not make me feel any better about this incident nor the fact that I was told NOTHING about side effects by my vet. And that for the first week my vet refused to even entertain the idea that the Rimadyl caused Carly's condition. He has since changed his opinion."
bursek@rpi.edu
Update on Case #16:
October 31, 1998: "Carly is doing wonderfully. I have gotten so many e-mails about her condition and Rimadyl. I think her story has helped so many dogs. I always tell my husband, she is truly an 'Angel with paws.' She came to us in the worst condition, and then to go through the Rimadyl reaction! We can't believe she's survived."
bursek@rpi.edu

4/9/99 Update on Case #16:
Pfizer Vet Remains Sincerely Concerned Following Rimadyl Reaction (Coordinator's Note: In the case of this dog, "Carly," the vet who prescribed Rimadyl refused to believe the dog's critical condition could have been Rimadyl-induced. It was the Pfizer vet who, when contacted by telephone, diagnosed it and, the owner feels, saved her dog's life.) "One of the vets who manages vet services for Pfizer, and who helped diagnose Carly's case as a toxic reaction to Rimadyl, was kind enough to call me at Christmas after I had sent him a card updating him on Carly's condition. I must have been very lucky to have gotten him. He even gave me his HOME phone number to call if Carly got worse ( this was while she was in critical condition). I feel he had more to do with her recovery then my now-ex-vet did. I was amazed that he actually took the time to call me at work to thank me for keeping in touch."
matisse@klink.net

Case #15:
Transferred to Deaths

Case #14:
Breed: Samoyed (female, "Cady")
Age: 9 years
Reason for Rimadyl rx: arthritis
When reaction occurred following initial dose: 10 days
Symptoms: vomiting; inappetance; bright yellow urine; jaundice; elevated liver enzymes and bilirubin
Date of episode: May 1998
Vet informed about side effects: YES
Current condition: recovering
Owner's Remarks: "After a couple of days, her liver enzymes came down, but her bilirubin, after an initial decrease, skyrocketed. The vet was very concerned. Thankfully, after two more days of 'flushing,' her bilirubin dropped, too."
ckau@earthlink.net

Case #13:
Breed: Greyhound (male, "Cody")
Age: 7 years
Reason for Rimadyl rx: neck pain
When reaction occurred following initial dose: 3 days
Symptoms: vomiting; diarrhea; hemmorhaging
Date of episode: May 1998
Vet informed about side effects: Vet told owner that many Greyhounds had been given Rimadyl with no adverse side effects
Current condition: recovering
Owner's Remarks: "The coincidence of starting the Rimadyl and then having the hemmorhaging leads us to suspect that Rimadyl was the cause, although we are not interested in testing the theory out on this poor dog.
adamel@applique.dh.trw.com

Case #12:
Breed: Black Lab (female, "Ebonie")
Age: 10 years
Reason for Rimadyl rx: neck pain
When reaction occurred following initial dose: after 8 to 10 months (drug was used intermittently during this period)
Symptoms: anemia; weight loss
Date of episode: Late 1997 through 1998
Vet informed about side effects: NO; called Pfizer at suggestion of dog owner and was given information concerning occurrence in Labradors
Current condition: developed drug-resistant urinary tract infection while recovering; owner believes condition to be Rimadyl-induced; celebrated 11th birthday on May 7, 1998
Owner's Remarks: "Remember, if your dog suffers an adverse reaction from Rimadyl, it hits FAST AND FURIOUS. Please, have your dogs monitored regularly if they are taking this drug. By the time I suspected Ebonie might be ill, she was nearly gone."
November 27, 1998 Update: "Ebonie suffered with anemia and what I believe to be a serious and Rimadyl-related kidney infection. She now appears so big and strong most of the time that it amazes me. She has gained almost 15 pounds (needed) since her near-death experience while on Rimadyl. There are some days when I feel she may seem a little 'off,' and I become alarmed wondering if she is having some type of delayed reaction to Rimadyl. However, so far I am very happy with her recovery. I know of two people who are using Rimadyl for their pets. One dog is a senior lab mix, and the other is a senior miniature dachshund. The vet informed the dachshund owner that he has yet to see a dachshund have an adverse reaction to Rimadyl. The vet treating the lab mix had heard NOTHING about the reactions. I informed them both they better pray that if their pets do have a reaction that they will get a second chance like Ebonie and I did."
LVBLUBRDS@aol.com

Case #11:
Breed: Chocolate Lab (male, "General Barksdale")
Age: 15 months
Reason for Rimadyl rx: post-operative medication following elbow surgery
When reaction occurred following initial dose: 5 days
Symptoms: inappetance; excessive urination; dark urine; elevated liver enzymes and bilirubin; yellow eyes
Date of episode: April 1998
Vet informed about side effects: initially suspected leptosporosis (rare where the General lives)
Current condition: fully recovered
Owner's Remarks: "As of his last blood test at the end of June 1998, the General's liver enzymes were all normal, and he is a happy healthy dog once again. I still worry about long-term effects, but, for today, we can report that he is terrific!"
BKLIEG@aol.com

Case #10:
Breed: Doberman (male, "Beau")
Age: 10 years
Reason for Rimadyl rx: arthritis; possible spinal column tumor
When reaction occurred following initial dose: several months
Symptoms: seizure; diabetes; elevated blood counts
Date of episode: Spring 1998
Vet informed about side effects: not clear; dog also taking prednisone and soloxine
Current condition: has continuing symptoms
Owner's Remarks: "Beau improved virtually overnight (after taking Rimadyl), walking better and appearing more energetic. But two days ago, he had a seizure; his legs extended stiffly and his jaws opened wide and he frothed at the mouth slightly."
Jaspenn@aol.com

Case #9:
Breed: Siberian Husky (female, "Sabrina")
Age: 11 years
Reason for Rimadyl rx: pulled shoulder muscle
When reaction occurred following initial dose: 24 hours
Symptoms: refusal to drink water; refusal to urinate; dark stools; panting; restlessness; subsequent incontinence and urinary tract infection even after Rimadyl was stopped
Date of episode: February 1998
Vet informed about side effects: YES; however, gave no warning to owners; without consulting owners, decided not to do baseline tests since administration of drug was to be short term
Current condition: recovering
Owner's Remarks: "It seems pretty obvious that Sabrina had no pre-existing condition, and that it was Rimadyl that caused her to become sick. We continue to be concerned about her high liver values -- why they have kept climbing even though she is no longer on the drug. 'Recovering' is a good way to describe her, but will she recover completely? We do not know yet."
Mary Gadbois, East Lyme, CT

Case #8:
Breed: Yellow Lab (male, "Jake")
Age: 8.5 years
Reason for Rimadyl rx: front leg limp
When reaction occurred following initial dose: 8 months
Symptoms: diarrhea; low platelets; enlarged spleen
Date of episode: March 1997
Vet informed about side effects: NO; gave no warning to owners; did no baseline tests
Current condition: improving
Owner's Remarks: "No one seemed to pay any attention when I brought up the fact that he was on Rimadyl. I did call Pfizer and talk to one of their staff vets who told me to take him off (which I did after the diarrhea persisted a second day). My vet is not familiar with Rimadyl and seems afraid to use it, as it is so new. I spoke with the vet who had prescribed it for Jake, and he said never to give it to him again. I won't. No one will really say if they think the thrombocytopenia that Jake was suffering from could have been caused by Rimadyl. We currently have him on 10mg of prednisone every other day, and that keeps his platelets even. It has also completely eliminated his limp. I know there are side effects related to prednisone, but at least I know what they are. I cannot say for sure that Rimadyl caused Jake's problem, but he has been tested for everything known to man and dog, x- rayed, ultrasounded -- you name it, we tested for it -- and found nothing."
MRSEMUZZ@aol.com

Case #7:
Breed: Husky (female, "Nicki")
Age: 5 years
Reason for Rimadyl rx: arthritis
When reaction occurred following initial dose: 4 days
Symptoms: inappetance
Date of episode: May 1997
Vet informed about side effects: NO; initially diagnosed kidney failure
Current condition: see update below
Owner's Remarks: "They knew nothing about the possible side effects of Rimadyl, and tried dismissing my claims -- until I showed them the printout from Pfizer, which listed renal failure. Thank God I got to this site, or I'd probably still be pumping her full of the stuff."
bkdreams@one.net
Case #7 Update:
Current condition: Addison's disease diagnosed, which had
unknowingly been causing her renal problems. Rimadyl was prescribed by a surgeon with no preliminary testing, even though he was informed she may have had a bladder or kidney infection. He recommended taking dog to her primary vet for kidney work-up and did not feel it was necessary to do any prior to administering Rimadyl. Preliminary blood work would have shown elevated values indicating serious kidney problems. Primary vet withdrew Rimadyl, saying 'It's too new, we don't know enough about it.' Hospitalized twice, received IV fluids, was sent home and faded again. Primary vet consulted an internist, who suggested testing for Addison's. She was finally diagnosed and is being treated; has begun responding to the medication.
Owner's Comments: "Nicki is now doing well. She's not as perky as before, but is in pretty good shape. She's back to running with me in the mornings and is still improving. Had the surgeon done the recommended preliminary testing, all this could have been avoided. I contacted the surgery clinic, laid all the information out in chronological order, but the surgeon flatly refused to accept any responsibility. Nicki's primary vet told me he has dispensed Rimadyl, but never without preliminary blood work." bkdreams@one.net
This is an abbreviated report; complete report available upon request to: rimreport@srdogs.com

Case #6:
Breed: Lab Mix (male)
Age: 7 years
Reason for Rimadyl rx: post-surgical
When reaction occurred following initial dose: 4 days after beginning full dosage; initial 1/2 dosage did not produce side effects, but also did not improve dog's condition
Symptoms: diarrhea; black, tarry stools; weakness, stumbling
Date of episode: December 1997
Vet informed about side effects: NO
Current condition: no current report
Owner's Remarks: "There was some question about whether he would survive. He did recover because of quick medical attention. At the time I questioned the vet(s), none of them were aware of Rimadyl's side effects."
Pef6436@aol.com

Case #5:
Breed: Minpin (male)
Age: 11 years
Reason for Rimadyl rx: degenerative joint disease, arthritis
When reaction occurred following initial dose: 10 days; after second administration, several days
Symptoms: staggering, stumbling
Date of episode: Late 1997
Vet informed about side effects: not clear; vet prescribed it in two different courses, even after knowing of dog's reaction to first dose
Current condition: no current report
ALFACOYOTE@aol.com

Case #4:
Breed: Yellow Lab (male)
Age: 9 years
Reason for Rimadyl rx: arthritis
When reaction occurred following initial dose: 7 days
Symptoms: depression; inappetance; loss of motor control
Date of episode: Spring 1998
Vet informed about side effects: NO; did not believe Rimadyl to be involved; Pfizer subsequently agreed Rimadyl was implicated and paid vet bills
Current condition: recovered
Owner's Remarks: Owner withdrew name after accepting payment from and signing agreement with Pfizer.

Case #3:
Breed: Lab/Shepherd Mix (female, "Soxi")
Age: 5.5 years
Reason for Rimadyl rx: arthritis
When reaction occurred following initial dose: 8 months
Symptoms: inappetance; vomiting
Date of episode: February - October 1997
Vet informed about side effects: "Our vet was told exactly what all the other vets were told about Rimadyl in Jan/Feb 1997: it was safe, a 'miracle' drug, and might cause minor stomach upset.
Current condition: recovered
Owner's Remarks: "Paul (our vet) was quick to agree during Soxi's second episode with Rimadyl that it was the only thing in common and therefore had to be the cause of her decline. Pfizer wouldn't admit to it and even went so far as to deny it was the drug; however both Paul and I were ignorant of the real danger and I asked Paul to have Pfizer test the pills we had for contamination. We thought that might be the cause. Pfizer took 5 months to return their report to us -- no contamination. Glad I didn't hold my breath! If you have a 'survivor,' don't stop watching! I know this sounds like I am paranoid - well, I am, and I'm not ashamed to admit it. My girl's life and well-being are at stake. Even if she merely sneezes, I watch and observe: is it a one-time occurrence? how long does it last? does it come back again? how long apart? It was ignorance that nearly took her life, but it is knowledge that will keep her as healthy as possible."
This is an abbreviated report; complete report available upon request to: rimreport@srdogs.com
3/9/99 Update on Case #3:
(Coordinator's note: Rimadyl was a factor in the death of one of the writer's dogs, "Ginger," and almost killed Soxi.) "Soxi goes to the vet every 4 months for her complete physical and lab work. Her vet screens her closely since witnessing the terrible side effects Rimadyl caused in her case. He watched her nearly die.  Paul, our vet, was told exactly what all the other vets were back in Jan/Feb 1997: Rimadyl was supposed to be a safe, 'miracle' drug, causing minor stomach upset perhaps. He was quick to agree, however, during Soxi's second episode with Rimadyl that it was the only thing that could explain her decline. Pfizer wouldn't admit to it and even went so far as to deny it was the drug. We thought that perhaps the pills had been contaminated somehow and asked Pfizer to test them. Pfizer took 5 months to return their report to us -- no contamination. Glad I didn't hold my breath! Thanks to Paul's concern, his love for animals, and his lack of inflated ego, he has become very enlightened and cautious about prescribing Rimadyl. He informs his clients of the real risks and runs lab work and physicals prior to administering the drug. He begins with a low dosage and gives it only when the dog is a true candidate for Rimadyl. Soxi's last lab tests and physical show a healthy dog. Recently, however, she began crying out with pain after lying for some time and trying to get up. The vet and I decided x-rays were necessary. We found the right hip is dysplastic and there is arthritis in the left knee. Nothing new here, but it was good to know there was nothing else wrong. The vet has now put Soxi on Cortaba, and it has helped. The side effects are possible gastric upset and ulcers. We are working her down from 1 tablet in the a.m. to 1/2 tablet in the a.m. and the other 1/2 in the p.m., eventually getting her to 1/2 tab a day. She is still taking 3 tablets of Glycoflex daily. It is so good to see her running and feeling good again."
callahan@scra.org

Case #2:
Breed: Yellow Lab (male, "Kris Kringle")
Age: 3.5 years
Reason for Rimadyl rx: elbow dysplasia
When reaction occurred following initial dose: 3 weeks
Symptoms: inappetance; vomiting
Date of episode: April 1998
Vet informed about side effects: NO; suggested symptoms indicated poisoning from wild mushrooms
Current condition: recovered
Owner's Remarks: "Our vet told us he would not expect to see these types of symptoms from Rimadyl and that it could be from wild mushrooms. I called the Pfizer problem hotline. I described Kris' symptoms, the fact that he was young, had no other health problems and was not on any medication other than Rimadyl. The Pfizer veternarian agreed that this looked like a classic case of Rimadyl side-effects."
ameblin@aol.com

Case #1:
Breed: Unknown (male, "Rudy")
Age: senior
Reason for Rimadyl rx: arthritis
When reaction occurred following initial dose: 3 weeks
Symptoms: inappetance; vomiting
Date of episode: April 1998
Vet informed about side effects: NO! Definitely NOT!!
Current condition: permanently disabled
Owner's Remarks: "In December, I arrived home to find that my dog, Rudy, could not keep his balance. He had the same eye twitch ... as Beau (see Death #33 above). At first, I thought it was some infectious disease passed on to him by Beau. By the next day, I began to suspect Rimadyl. Rudy had not been on it as long as Beau. I contacted my vet, who called Pfizer. They did not acknowledge that there had been any other reports of this type of reaction. It was also at this time that I decided to research the information available on the Internet. It seems that this reaction may be more common than Pfizer wants to admit. I personally know of three other dogs in Tallahassee who died or had to be put to sleep after having the same type of problem. My beautiful Beau hung on as long as possible, until I finally had to admit that his quality of life was gone. Rudy seemed to fully recover but had a relapse a couple of weeks ago, and I'm afraid he will never return to his active life. Veterinarians who do not pay attention to all the reported side effects are dooming some dogs to death and their owners to horrible heartache. Rudy was in perfect health other than his stiff joints. He had had lab work done a couple of months before we put him on Rimadyl, and his liver function was normal. Now he has to be on a special diet. "
troost@webtv.net

Unclassified Report (8/16/98)
Breed: Black Lab (male)
Age: 14 years
Reason for Rimadyl rx: stiffness in legs
When reaction occurred following initial dose: not certain; dog took drug for 8 months
Date of death: August 1998
Vet informed about side effects: did not warn owner
Owner's Remarks: "I am very upset that I was NEVER told anything about side effects -- only that Rimadyl was a good product and it would help my dog. I think the vet should have made me aware of any problems associated with Rimadyl. It might save a dog's life if owners were told something simple like the TRUTH."
<jwdol@doitnow.com>